Lvsa significantly attenuated leadinduced nephrotoxicity. Lead and cadmium are the two most commonly known nephrotoxic metals. Moreover, great at tention should be paid to drug interactions. Thus, this study has been designed to investigate the effect of low viscosity sodium alginate lvsa in lead induced nephrotoxicity. Renal vulnerability to drug toxicity american society of. Lead has many good uses, but too much can be harmful to humans and animals.
Erythrophagocytosis of leadexposed erythrocytes by renal. Effect of curcumin on inflammation and oxidative stress in. One, two, or all three of the factor categories can act to promote various forms of renal injury. Mice were exposed chronically to lead acetate, at a dose of 5 mgkg, alone or in conjunction with b. The aim of this work was to study the effect of natural honey on cadmiuminduced liver and kidney damage. Epidemiological and toxicological studies have reported lead induced toxicity in the nervous, cardiovascular, and renal systems agency for toxic substances and disease registry atsdr 2007. Autophagy blockade and lysosomal membrane permeabilization. Jan 15, 2016 lead is a biohazardous metal that is commonly involved in human illness including renal injury. Luteolin lut a flavonoid present in various plant products is well known for exhibiting numerous pharmacological properties.
Some of the reason for this is that chronic renal disease from lead exposure does not become evident until late in life and usually after many years of excessive exposure. As the list of drugs, natural products, industrial chemicals and environmental pollutants that cause nephrotoxicity. The 6rs of drug induced nephrotoxicity linda awdishu1,2 and ravindra l. Introduction lead pb is a heavy metal distributed into the environment from natural and anthropogenic sources and. Investigating nephrotoxicity with an integrated liver. Cadmium and lead are divalent cations with a propensity to settle in the proximal tubule of the nephron, leading to nephrotoxicity. In this condition the kidney function deteriorates and may lead to chronic kidney failure. Luteolin protects against lead acetateinduced nephrotoxicity. The aim of the present study is to clarify the possible corrective role of curcumin on the nephrotoxicity induced by lead acetate. Methotrexate induced nephrotoxicity is not uncommon, although intrarenal methotrexate crystals have been elusive. It induces nephrotoxicity with significant alterations in renal structure and function.
Silymarin and dimercaptosuccinic acid ameliorate lead. Historical perspective of nephrotoxicity toxicological. Nephrotoxicity is a major complication and a dose limiting factor for cisplatin therapy. Thus nephropathies are generally classified as acute or chronic renal failure, malignancies or.
Sabah ansar 1, sarah farhat2, aljohara am albati 3, manal abudawood 1, sherifa hamed4 1clinical laboratory sciences, applied medical sciences, king saud university, saudi arabia 2lawrence high, lawrence, kansas, usa 3clinical health sciences, applied medical sciences, king saud university, saudi arabia. Protective effects of piperine on lead acetate inducednephrotoxicity. Drug induced nephrotoxicity is responsible for 20% to 60% of cases of acute kidney injury in hospitalized patients and is associated with increased morbidity and mortality in both children and adults. The current study was aimed at exploring the protective efficacy of spirulina against the hematobiochemical alterations and nephrotoxicity induced by lead pb. The association between lead exposure and nephrotoxicity has been wellestablished, even in a population with blls as low as 5.
Nephroprotective activity of solanum xanthocarpum fruit. Figure6 various sites of the drug induced nephrotoxicity the nephrotoxic substances causes nephrotoxicity. Lead poisoning is a type of metal poisoning caused by lead in the body. In recent years gentamicin nephrotoxicity is significantly reduced by shifting to once daily dosage as well as by eliminating known risk factors. Pathophysiologic mechanisms of selected types of nephrotoxicity. The clinical diagnosis of lead nephropathy is complex, because the symptoms are varied and nonspecific especially with subclinical nephrotoxicity. Lead acetate, berberis vulgaris, mice, nephrotoxicity, antioxidant enzymes, lipids peroxidation. Mar 31, 2015 molecular mechanism of drug induced nephrotoxicity 1.
Pdf lead pollution is one of the most important problems of environmental and occupational origin and is widely regarded as risk to health. Drug induced kidney disease occurs primarily in patients with underlying risk factors. Abstract of research paper on chemical sciences, author of scientific article talib hussain, ramesh k gupta, k sweety, bavani eswaran, m vijayakumar, et al abstract objective to evaluate nephroprotective potential of solanum xanthocarpum s. Based on the study, it can be stated that lead induced nephrotoxicity particularly. They are broadly categorized as patientspecific, kidneyrelated, and drugrelated factors. Victoriya sidorenko and colleagues elucidate the specific steps in the liver and kidney that lead to aristolochic acid.
Medical and environmental applications of activated charcoal. Ijms free fulltext cadmium transporters in the kidney. Cadmium accumulates in renal tubular lining cells bound to metallothionein, a small protein contain ing 3070 cystine. Chinese herbal medicine is composed mainly of natural compounds with complex active ingredients that can lead to varying degrees of side effects.
Acute nephrotoxicity consists of proximal tubular dysfunction and can be reversed by treatment with chelating agents. Microanatomy and histomorphometry analysis of the effects. Nephrotoxicity is a complication due to the effect of some toxic chemicals on kidneys. Toxicology letters, 46 1989 153162 153 txl 02127 mechanisms of lead and cadmium nephrotoxicity r. Dec 27, 2019 aminoglycosides preferentially affect the proximal tubular cells. Indigofera oblongifolia mitigates lead acetate induced kidney damage and apoptosis in a rat model mohamed a dkhil,1,2 mohamed s alkhalifa,1 saleh alquraishy,1 rafat zrieq,3 ahmed esmat abdel moneim2 1department of zoology, college of science, king saud university, riyadh, saudi arabia. It is important for the treatment of acute and chronic free radical mediated diseases and toxicity. Potential complications of lead nephropathy include gout and hypertension. Jun 12, 2017 children with high lead exposure mean, 23. Mar 24, 2017 due to high relative blood flow the kidney is prone to drug induced damage. Leadinduced chronic renal failuredefinitionlead pb nephrotoxicity relates to experimental, epidemiologic, and clinical evidence of renal damage and hypertension associated to environmental or occupational pb exposure. C 7, 10, 32, 48 druginduced renal impairment is generally reversible, provided the nephrotoxicity is recognized early and the offending medication is discontinued. Efficacy of curcumin on lead induced nephrotoxicity in.
Indigofera oblongifolia mitigates leadacetateinduced kidney. Effect of curcumin and curcumin nanoparticles against lead induced nephrotoxicity. Pdf lead induced nephrotoxicity with special reference to. Oxidative stress plays a key role in lead pbinduced nephrotoxicity. There has been a growing awareness that nephrotoxicity represents a key factor in human nephropathies, where, irrespective of the causative agent, only a few clinical endeffects are diagnosed. Acute methotrexateinduced crystal nephropathy nejm. Chitosan pinus merkusii nanoparticles were identified by particle size analysis psa and scanning electron microscope sem. Seventytwo adult male rats were equally divided to 6 groups. Read lead reduces the nephrotoxicity of mercuric chloride, ecotoxicology and environmental safety on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. These substances can include molds and fungi, cancer therapeutics such as cisplatin, antibiotics such as aminoglycosides, metals such as mercury, arsenic and lead, and drugs of. Jul 01, 2010 data revealing the daytoday variations in scr level in a large group of patients who presumably had the same prevalence of risks to kidney function, including diabetes, as any large randomly chosen population of hospitalized patients 4 show that the range of such variations is just as large as those variations attributed to cm administration in nearly all published series and is even more. Drug induced nephrotoxicity is defined by the presence of any kidney injury caused directly or indirectly by medication.
Luteolin ameliorates colistininduced nephrotoxicity in the. Although it is a nonredox reactive metal, leadinduced renal injury is largely based on oxidative stress. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. This study aimed to investigate the potential effects of berberis vulgaris l. Cadmium transporters in the kidney and cadmiuminduced. Nephrotoxins are chemicals displaying nephrotoxicity. Role of cadmium and lead in nephrotoxicity edelweiss publications. Drug induced nephrotoxicity is caused by nephrotoxic drugs or toxins which damage kidneys and can lead to nephritis or renal toxicity.
Nephrotoxicity results from lead exposure because the kidney is the main route by which lead is eliminated. Searching pubmed using nephrotoxicity as the search term results in 16,008 related papers, with the earliest paper cited describing the nephrotoxicity induced by cystine. Cisplatin induced nephrotoxicity is characterized by renal proximal tubular cell dysfunction. The present study was performed to explore the effect of curcumin against cisplatin induced experimental nephrotoxicity.
In another study, the inhibition of enzymes apn, rdp, and cs lyase did not protect rats given 10 mgkg of cisplatin andor rats treated with 6 mgkg from cisplatin induced nephrotoxicity. Evaluation of urinary excretion of exosomal oat5 after nacetylcysteine prevention of cisplatin induced nephrotoxicity. This study evaluated the effects of lead exposure on the histoarchitecture of kidney, assessed the effects of lead on the levels of creatinine, urea and albumin in the plasma and determined the effects of m. Cnis lead to activation of the major vasoconstriction systems, such as the reninangiotensin and endothelin systems, and increase sympathetic nerve activity. Protective effect of nacetylcysteine on experimental chronic. Current study planned to screen the effect of coriander and fennel aqueous seeds extracts on lead induced nephrotoxicity.
This case shows methotrexate crystals deposited within the kidney tubules of a pati. Effect of curcumin and curcumin nanoparticles against lead. This was with a view to providing information on the ameliorative effects. These substances can include molds and fungi, cancer therapeutics such as cisplatin, antibiotics such as aminoglycosides, metals such as mercury, arsenic and lead, and drugs of abuse such as cocaine.
Antimicrobials are one of the most common classes of medications prescribed globally and also among the most common causes of nephrotoxicity. Bennett, md division of nephrology, hypertension, and clinical pharmacology oregon health sciences university portland, oregon, usa the kidney is the major site of damage from many drugs and chemicals that are used in clinical medicine and are present in our environment. Curcumin is claimed to be a potent antiinflammatory and antioxidant agent. Nephrotoxicity and agents responsible nephrotoxic injury is damage to one or both kidenys that result from exposure to a toxic substance. The therapeutic properties of natural honey once considered a form of folk or preventive medicine. To provide cutting edge care for these patients, nephrologists and oncologists must be familiar with the nephrotoxicity of these drugs. The aim of this study was to evaluate the antioxidant activity of chitosan pinus merkusii extract nanoparticle on lead acetate induced toxicity in rat pancreas. A number of factors have been identified as adding risk to the development of tdf induced nephrotoxicity including advanced age, low body mass index bmi, diabetes mellitus dm, hypertension htn, couse of other nephrotoxic drugs such as protease inhibitors pi and didanosine, treatment experience, and genetic polymorphism in transporters involved in regulating tdf intracellular. Lead exposure and kidney function lead is a natural element found in small amounts in the earth. Oxidative stress can play a key role in cadmiuminduced dysfunction. Pdf protective effects of piperine on lead acetate induced.
On the basis of available evidence, we hypothesized that lead induced ps externalization in erythrocytes promotes erythrophagocytosis by renal tubular cells, contributing to lead associated kidney. Nephrotoxicity can be defined as the adverse effect of substances on renal function perazella, 2009. These agents are freely filtered by the glomeruli and quickly taken up by the proximal tubular epithelial cells, where they are incorporated into lysosomes after first interacting with phospholipids on the brush border membranes. Mechanisms of antimicrobialinduced nephrotoxicity in. Goyer department of pathology, university of western ontario, london, ontario, n6a 5c1 canada summary exposure to lead results in accumulation in proximal renal tubular lining cells in the form of mor phologically discernible inclusion bodies which are lead protein complexes. A number of factors enhance the vulnerability of the kidney to the nephrotoxic effects of drugs and toxins. Aminoglycoside type antibiotic gentamicin is one of the leading cause of drug induced nephrotoxicity.
Lead induced chronic renal failuredefinitionlead pb nephrotoxicity relates to experimental, epidemiologic, and clinical evidence of renal damage and. Relationship between various biological exposure indices and early markers of nephrotoxicity, american journal of industrial medicine on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The present study was performed to explore the effect of curcumin against cisplatin. Metallothionein protects against nephrotoxicity by binding cadmium in a nontoxic form. Nephrotoxicity and chinese herbal medicine american society.
Investigating nephrotoxicity with an integrated liverkidney chip. Pathophysiological mechanisms of calcineurin inhibitor. Female rats aged 12 weeks were treated for 4 weeks with pb 0. Silymarin and dimercaptosuccinic acid ameliorate lead induced nephrotoxicity and genotoxicity in rats show all authors. Original article nephroprotective effect of low viscosity. Chronic lead nephrotoxicity consists of interstitial fibrosis and progressive nephron loss, azotaemia and renal failure. It seems that an enhanced activity of mts contributes to cadmium induced nephrotoxicity. Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies.
Lead acetate nephrotoxicity, glomerular blood flow, oxidative stress, low viscosity sodium alginate, proximal convoluted tubules. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate gfr, can be dose limiting. Drug induced kidney diseases np singh, a ganguli, a prakash abstract drug induced kidney disease constitutes an important cause of acute renal failure and chronic kidney disease in present day clinical practice. Dosedependent effect of coriander coriandrum sativum l. The presentation varies from an acute or chronic reduced glomerular filtration rate gfr to nephrotic syndrome and hydroelectrolytic disorders hed related, respectively, to glomerular and tubular damage. Lead reduces the nephrotoxicity of mercuric chloride. More side effects increased nephrotoxicity change in the drug metabolism 4.
Epidemiological and toxicological studies have reported leadinduced toxicity in the nervous, cardiovascular, and renal systems agency for toxic substances and disease registry atsdr 2007. The current study was carried out to evaluate the antioxidant and anticaspase 3 activity of chitosan pinus merkusii nanoparticle in against lead acetate induced nephrotoxicity in rats. Recent evidence suggests that inflammation and oxidative stress may contribute to the pathogenesis of cisplatin induced acute renal failure. Nacetylcysteine nac is a potent oxygen free radicals scavenger and a metal chelator. This may reflect a true phenomenon because lead exposure has been reported to accelerate bony maturation by inhibiting the effects of parathyroid hormonerelated peptide. Research, report by environmental health perspectives. Edelweiss applied science and technology, 2018 pdf. Health, general environmental issues erythrocytes physiological aspects kidney diseases risk factors lead health aspects lead metal red blood cells. The causative drug must be identified and its use must be. Nephroprotective effect of costus afer on lead induced kidney.
Some of these herbal medicines are also known to cause nephrotoxicity, which is often overlooked by physicians and patients due to the belief that herbal medications are innocuous. Risk factors for chemotherapy induced nephrotoxicity. Donaldsoneffect of lead toxicity on the organ concentration of glutathione and glutathionerelated free amino acids in the chick. Despite the recognition of lead nephropathy as a consequence of environmental and occupational lead exposure, lead nephropathy still appears to be underrecognized by physicians as a cause and promoter of chronic kidney disease ckd, especially in people with more apparent causative factors such as diabetes and hypertension. Erythrophagocytosis of lead exposed erythrocytes by renal tubular cells. Understanding and managing methotrexate nephrotoxicity. Nephrotoxicity, biochemical alterations, lead, allium sativum, vitamin c, rats. Prediction of druginduced nephrotoxicity and injury. Onconephrology is a new area that is rapidly expanding and requires a close working relationship between oncologists and nephrologists. Lead exposure and kidney function national kidney foundation.
Preventing nephrotoxicity induced by lead in albino rats. Data from clinical studies are not conclusive regarding the role of zinc transporters in cadmium induced nephrotoxicity. In the present study we examined the role of erythrocytes in lead induced nephrotoxicity in vitro in a coculture system as well as in vivo in rats. Pathophysiology of nephrotoxic acute renal failure h umans are exposed intentionally and unintentionally to a variety of diverse chemicals that harm the kidney. It causes almost 10% of intellectual disability of otherwise unknown cause and can result in behavioral problems. The pathophysiological results, however, tend to diverge. Nephrotoxins are substances displaying nephrotoxicity nephrotoxicity should not be confused with the fact that some medications are predominantly excreted by. Lead pb toxicity remains a significant public health problem because of its global pervasiveness and its adverse effects on the renal system. Mda may be used as an indicator of cell membrane damage after exposure to ros and free radicals. Lead is one of the heavy metals with oxidative stress that causes toxicity in human and animals. Ac may be beneficial in chronic lead induced liver and kidney damage. Chronic lead exposure has been implicated in renal failure in. Adverse renal effects occur because of innate drug toxicity and a number of patient and drugrelated factors.
Lead induced hepatorenal damage in male albino rats. The high level of lead exposure required to cause lead nephropathy is now increasingly rare, particularly in developed countries. Oxidative stress plays a key role in lead induced nephrotoxicity. Protective effects of piperine on lead acetate inducednephrotoxicity in rats. The nephrotoxic effect of a single intraperitoneal dose of mercuric chloride hgcl 2. Despite dramatic improvements in patient survival and drug tolerability, nephrotoxicity remains an important complication of chemotherapy. Finally, determination of a patients or donors genotype of drugmetabolizing genes or of mol ecules involved in csa nephrotoxicity. They had free access to standard rat pellet diet and water ad libitum. Mechanisms of lead and cadmium nephrotoxicity sciencedirect. There are various forms, and some drugs may affect kidney function in more than one way. We evaluated the protective efficacy of lut against pb induced renal injury in male wistar. On the other hand, cnis are known to inhibit no synthesis and nomediated vasodilation and to increase free radical formation. Different classes of drugs, by virtue of immunological mechanisms or direct toxicity initiate certain stereotyped renal responses. Nov 15, 2007 recent evidence suggests that inflammation and oxidative stress may contribute to the pathogenesis of cisplatin induced acute renal failure.
Lead pb is one of the most common heavy metal pollutants affecting living organisms. With acute lead nephrotoxicity, these lead protein complexes are observed as typical intracellular inclusions. At the point when kidney harm happens, patient cannot free his assortment of. Lead is absorbed by the proximal tubular cells of the renal tubules, where it binds to specific lead binding proteins. Chronic nephropathy is one of the oldest recognized health effects of lead. Gammaglutamyl cysteine attenuates tissue damage and enhances. Reports of nephrotoxicity research continue to increase each decade with only 80 articles before 1970 to over 5300 papers between 2010 and 2018. Oxidative stress represents an imbalance between the production of free radicals and the. Protective effects of spirulina against hematobiochemical. Lead induced oxidative stress and its recovery following coadministration of melatonin or nacetylcysteine during chelation with. Nephrotoxicity definition of nephrotoxicity by the free. Our current knowledge of drug induced kidney disease is. Erythrophagocytosis of leadexposed erythrocytes by renal tubular cells.
Jul 27, 2015 drug induced nephrotoxicity can lead to acute kidney injury aki or chronic kidney disease in patients and is a major problem for clinicians 2,3. If unchecked, the kidney failure may lead to the death. While protection is temporally associated with lead induced mitosis, occurring about 39 h after intracardiac lead. Symptoms may include abdominal pain, constipation, headaches, irritability, memory problems, inability to have children, and tingling in the hands and feet. Organic anion transporter 5 oat5 urinary excretion is a specific biomarker of kidney injury. The potency of chitosanpinus merkusii extract nanoparticle. Mehta2 abstract drug induced kidney injury is a frequent adverse event which contributes to morbidity and increased healthcare utilization. The current work aimed at exploring the possible protective effect of. The increase in mda levels in kidney suggests that antioxidant failure to inhibit ros and formation of free radicals can enhance lipid peroxidation causing.